A CRO with innovative preclinical models specialized in the gut and gut-brain axis
Our CRO offers validated and innovative complete preclinical efficacy tests in vitro and in vivo.
Scientifically rooted in the gut, our experts offer a holistic approach focused on digestive physiology and the modes of communication between the gut and peripheral organs to enhance your assets. Explore our wide range of in vitro and in vivo preclinical and translational tests.
Explore the gut organ approach for your preclinical studies
GUT MICROBIOTA
GUT
LIVER
GUT
ADIPOSE
GUT
BRAIN
GUT
CARDIOVASC
GUT
SKIN
Click on the organ axis to find the preclinical models you need
GUT MICROBIOTA
GUT LIVER
GUT ADIPOSE
GUT BRAIN
GUT CARDIOVASC
GUT SKIN
Click on the organ axis to find preclinical models you need
IN VITRO GUT MICROBIOTA MODELS
2D intestinal epithelial cells
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Permeability & gut barrier function
- Absorption
- Cell renewal & differentiation
Coculture intestinal epithelial & immune cells
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Permeability & gut barrier function
- Absorption
- Cell renewal & differentiation
3D epithelial tissues
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Permeability & gut barrier function
- Absorption
- Cell renewal & differentiation
IN VIVO GUT MICROBIOTA MODELS
Diet induced “leaky gut” phenotype
- Antioxidant capacity
- Motility
- Immunomodulation
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Absorption
DSS induced colitis model
- Antioxidant capacity
- Motility
- Immunomodulation
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Absorption
Constipation model
- Antioxidant capacity
- Motility
- Immunomodulation
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Absorption
Diarrhea model
- Antioxidant capacity
- Motility
- Immunomodulation
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Absorption
INDICATIONS / PATHOLOGIES
- Chronic constipation
- Crohn’s disease
- Diarrhea
- Enteric neuropathies
- Irritable bowel syndrome
- Irritable bowel diseases
IN VITRO GUT LIVER MODELS
2D hepatocytes
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Enzyme activity
- Lipids metabolism & accumulation
- Glucose metabolism
- Detoxification
IN VIVO GUT LIVER MODELS
High Fat Diet induced steatosis
- Antioxidant capacity
- NAFLD scoring
- Immunomodulation
- Enzyme activity
- Lipids metabolism & accumulation
- Detoxification
INDICATIONS / PATHOLOGIES
- Hepatic steatosis
- Hypercholesterolemia
- Metabolic syndrome
- NAFLD / NASH
- Obesity
- Overweight
- Type 2 diabetes
IN VITRO GUT ADIPOSE MODELS
2D adipocytes in collaboration with Diva Expertise
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Lipids metabolism & accumulation
- Cell differentiation
DivaGuT model in collaboration with Diva Expertise
- Intestinal absorption
- Antioxidant capacity
- Immunomodulation
- Lipids metabolism & accumulation
- Cell differentiation
IN VIVO GUT ADIPOSE MODELS
High Fat Diet induced obesity model
- Body weight management
- Glucose metabolism
- Insulin resistance
- Lipid metabolism
- Antioxidant capacity
- Immunomodulation
- Gut motility
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Intestinal absorption
- Antibacterial activity
INDICATIONS / PATHOLOGIES
- Metabolic syndrome
- Obesity
- Overweight
- Type 2 diabete
IN VITRO GUT BRAIN MODELS
3D Minibrain (in progress)
- Viability & cytotoxicity
- Antioxidant capacity
- Neurite outgrowth
IN VIVO GUT BRAIN
MODELS
High Fat Diet induced obesity mode
- Antioxidant capacity
- Neurotransmission & central nervous system activity
- Immunomodulation
- Gut motility
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Intestinal absorption
Neurogenerative model (in progress)
- Antioxidant capacity
- Neurotransmission & central nervous system activity
- Blood brain barrier permeability
- Cognitive functions
- Immunomodulation
- Gut motility
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Intestinal absorption
Depression model (in progress)
- Antioxidant capacity
- Neurotransmission & central nervous system activity
- Blood brain barrier permeability
- Cognitive functions
- Immunomodulation
- Gut motility
- Neurotransmission & enteric nervous system activity
- Permeability & gut barrier function
- Intestinal absorption
INDICATIONS / PATHOLOGIES
- Alzheimer’s disease
- Depression
- Epilepsy
- Multiple sclerosis
- Parkinson’s disease
- Psychological stress
IN VITRO GUT CARDIOVASC MODELS
2D endothelial cells
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Vascular permeability
IN VIVO GUT CARDIOVASC MODELS
Isolated aorta
- Antioxidant capacity
- Vascular permeability
INDICATIONS / PATHOLOGIES
- Atherosclerosis
- Cardiovascular disorders
- Metabolic syndrome
- Obesity
- Overweight
- Type 2 diabetes
IN VITRO GUT SKIN MODELS
In vitro gut-skin model
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
- Permeability & gut barrier function
2D keratinocytes with SkinMecachipTM from Cell&Soft
- Viability & cytotoxicity
- Antioxidant capacity
- Immunomodulation
INDICATIONS / PATHOLOGIES
- Acne vulgaris
- Atopic dermatitis
- Depression
- Emotional disorders
- Psoriasis
- Rosacea
- Stress
Custom model for your preclinical studies on the gut and gut-organ axis
By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor-made models for efficiency testing
Custom model for your preclinical studies on the gut and gut-organ axis
By combining our R&D expertise, technological know-how and innovation process, we offer you new opportunities to differentiate and increase the value of your assets through the development of tailor-made models for efficiency testing
White paper ENTEROSYS
« GUT IS THE LINK »
Our first white paper is now available !
Get inside the head of our co-founder Claude Knauf.
Come discover his background, his key dates, how he got the gut feeling and the link between enteric neurons and glycemic control as well as other health related areas.
Do you have a question about the contribution of gut models in your innovative research ?
Our team of experts will be delighted to answer all of your questions. We guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.