Innovative preclinical investigations for metabolic disorders & diseases

Enterosys is a CRO scientifically rooted in the gut and its peripheral organs

The gut-brain axis provides bi-directional communication between the gastrointestinal and central nervous systems. It plays a fundamental role in the regulation of metabolism in our body, including the regulation of appetite, glucose and lipid homeostasis, and gastrointestinal function.

Current research suggests a much broader role of the gut-brain mechanisms in physiology and disease. Targeting these processes has become a major focus in the development of new molecules for therapeutic purposes. However, our current knowledge of these biological processes is limited, largely because of the lack of scientific tools to provide a detailed mechanistic understanding of gut-brain communication.

Research on the gut-brain axis has historically focused on the study of individual components of this system. And yet now, the state-of-the-art technologies and the holistic approach offered by Enterosys provide a better understanding of how signals from these biological components are orchestrated to regulate metabolism. Our innovative methods allow us to tap into new knowledge by exploring new approaches for the treatment of metabolic diseases and disorders.

AGING

Aging is usually associated with the development of a metabolic syndrome due to the disturbance of inter-organ communication.

HEPATIC FIBROSIS

Hepatic fibrosis corresponds to the formation of an abnormally large amount of scar tissue in the liver. Severe scarring of the liver can lead to cirrhosis, which causes various symptoms characteristic of liver disease.

METABOLIC SYNDROME

Metabolic syndrome is a pathological condition in which the body’s metabolism is altered. This condition results in the development of pathological conditions such as type 2 diabetes, obesity, cardiovascular disease, hepatic steatosis and stroke.

NON-ALCOHOLIC FATTY LIVER DISEASE

Non-Alcoholic Fatty Liver Disease (NAFLD) is defined by an excessive accumulation of lipids in hepatocytes which is not related to alcohol consumption. Two main entities can be distinguished: isolated steatosis or steatosis accompanied by minimal lobular inflammation (non-alcoholic fatty liver or NAFL) and non-alcoholic steatohepatitis (NASH).

NON-ALCOHOLIC STEATOHEPATISIS

Non-alcoholic steatohepatitis (NASH) is defined by the presence of steatosis with lobular inflammation and ballooning of the hepatocytes. This condition is an aggressive form of fatty liver diseases which favors the accumulation of fibrosis in the liver and leads to cirrhosis and its associated complications.

At the cutting edge of preclinical studies in metabolic diseases

Bioactive gut molecules called enterosynes from various origins can target enteric neurons and regulate their activity to restore a physiological gut-brain axis communication.

Figure from Knauf C, Abot A, Wemelle E, Cani PD. Targeting the Enteric Nervous System to Treat Metabolic Disorders? “Enterosynes” as Therapeutic Gut Factors. Neuroendocrinology. 2020;110(1-2):139-146. doi: 10.1159/000500602. Epub 2019 Jul 2. PMID: 31280267.

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