Dermocosmetics: revolutionizing skin health through a holistic approach
Dermocosmetics is the link between dermatology and cosmetics, offering products that not only enhance appearance but also provide therapeutic benefits to the skin. Unlike traditional skincare items, dermocosmetics are formulated with active ingredients targeting specific skin disorders. Their efficacy is often supported by preclinical and clinical studies, making them a preferred choice for individuals seeking both aesthetic and health benefits in their skincare regimen.
The gut-skin axis: interconnected pathways
The gut-skin axis, reciprocal influences and similarities
The gut and the skin share striking similarities in their structure and function, both acting as selective barriers in constant interaction with the external environment. These two organs are equipped with highly specialized immune systems, capable of identifying and responding to external threats while maintaining tolerance to beneficial microorganisms. Both are also richly vascularized and innervated, highlighting their neuroendocrine roles in regulating inflammation, immune responses, and overall homeostasis. Additionally, each hosts a unique microbiome, an ecosystem of microorganisms essential for maintaining balance, resilience, and optimal functionality.
Notably, over 75% of individuals with an intestinal pathology also present with a skin disorder, highlighting the strong clinical correlation between these two systems. Understanding and addressing the gut-skin axis holistically, therefore, represents a powerful strategy for managing and preventing related conditions.
The gut microbiota and skin inflammation
When dysbiosis, or microbial imbalance, occurs in either the gut or the skin, it can disrupt immune responses, triggering inflammation. This inflammatory state can manifest as skin conditions such as acne, psoriasis, and eczema, while chronic skin inflammation can, in turn, send stress signals that disrupt gut homeostasis. This bi-directional relationship highlights how the integrity of one barrier impacts the other, emphasizing the importance of maintaining a balanced microbiome in both systems for overall health.
The “In & Out” approach: a comprehensive vision in dermocosmetics
In dermocosmetics, the emerging “In & Out” approach represents a comprehensive and synergistic strategy to target skin health both internally and externally. This dual-action concept combines internal prevention and therapeutic care through dietary supplements, nutricosmetics, prebiotics, and probiotics (In), with external treatment using advanced topical formulations (Out). By addressing skin concerns from these two complementary angles, the “In & Out” approach ensures more effective, long-lasting results for skin health and appearance.
At Enterosys, we specialize in supporting the development of tailored “In & Out” active ingredient cocktails, designed to work together harmoniously. Our preclinical models allow us to study the combined effects of internal and external interventions, assessing their impact on skin. This personalized approach enables our partners to validate the efficacy and safety of their formulations, providing scientifically robust evidence that enhances product value and minimizes risks before entering clinical trials.
To push the boundaries of dermocosmetic research, Enterosys has developed an innovative method for the ultrasensitive detection of reactive oxygen species. This advanced technique allows us to accurately predict the antioxidant capacity of new skin treatment compounds, offering invaluable insights during the preclinical evaluation phase. By integrating this ultra-precise measurement technology into our preclinical studies, we can deliver high-resolution data on the bioactivity of compounds, enabling more predictive and reliable results for dermocosmetic innovations.
Collaborating with enterosys: tailored preclinical models for dermocosmetic success
By collaborating with Enterosys, dermocosmetic brands gain access to cutting-edge research protocols, customized preclinical models, and holistic strategies that align with the latest industry trends and consumer demands
Our expertise allows us to create tailored research protocols that address your unique challenges, ensuring that every study generates scientifically robust evidence to support your claims.
Contact us to know more about our expertise !
White paper ENTEROSYS
« GUT IS THE LINK »
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Get inside the head of our co-founder Claude Knauf.
Come discover his background, his key dates, how he got the gut feeling and the link between enteric neurons and glycemic control as well as other health related areas.
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