Intestinal barrier : key to digestion and nutrient absorption
Unlock the mystery of your digestive system! In this edition, we explore the vital roles of digestion and nutrient absorption, essential for maintaining health. Digestion is the process by which foods are broken down into smaller molecules, or nutrients, making them...
gut-health n°1
Have you ever wondered how your body turns the food you eat into the energy you need? The secret lies within the fascinating world of gut physiology. Your digestive tract is not just a simple tube for digestion—it’s a complex system designed to absorb essential...
Enteric neurons for functional applications in health care
In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.
Enteric neurons and glycemia control
In the intestine, gut distension and nutrients are detected by mechanoreceptors and chemoreceptors, respectively. The activation of these receptors sends an afferent nervous message to the hypothalamus in the brain. In turn, the hypothalamus controls the glucose entry in tissues, and thus glycemia.
The enteric nervous system is our second brain
The enteric nervous system (ENS), referred to as the “second brain,” is an extensive network of different cell types located along the digestive tract.
Antioxidant and anti-inflammatory properties of maternal milk
The high hydrostatic pressure processing of donor milk may better protect preterm infants from gut and liver pathologies compared to Holder pasteurization, which is currently used in most human milk banks.
Targeting our second brain using prebiotics
The discovery of intestinal actors, such as enterosynes, able to modulate the ENS-induced duodenal contraction is an innovative approach. Among all the intestinal factors, the understanding of the role of gut microbes in controlling glycaemia remains a major target. For instance, we researched and demonstrated how the modulation of gut microbiota by prebiotics could permit the identification of novel enterosynes.
Glucose is an Enterosyne with deleterious impact of insulin sensitivity
Targeting the enteric nervous system that controls gut motility is now considered as an innovative therapeutic way in T2D to limit intestinal glucose absorption and restore the gut‐brain axis to improve insulin sensitivity. So far, little is known about the role of glucose on duodenal contraction in fasted and fed states in normal and diabetic conditions.
How does the gut microbiota interact with our second brain?
Currently, the gut is considered a primary site for the development of pathologies that modify brain functions such as neurodegenerative (Parkinson’s, Alzheimer’s, etc.) and metabolic (type 2 diabetes, obesity, etc.) disorders. Deciphering the mode of interaction between microbiota and the brain is a real original option to prevent (and maybe treat in the future) the establishment of gut-brain disfunctions and associated pathologies.
Camu camu and its applications in nutraceutics
The Amazonian forests are home to a shrub, the camu-camu, whose fruit could be of great help in the fight against obesity and metabolic diseases. This is described in our latest study published with the A-Mansia R&D team in the journal Metabolites.
Preserve the bioactive factors of breast milk
Human breast milk donated to human milk banks is the sole diet for preterm infants when maternal BM is not available. Pasteurization of donated breast milk is an essential step to inactivate pathogens to ensure microbial safety for preterm babies. The study of intestinal motility can be used to optimize pasteurization processes.
Targeting our second brain to fight diabetes
The enteric nervous system (ENS) plays a key role in controlling the gut-brain axis under normal and pathological conditions, such as type 2 diabetes. The discovery of intestinal actors, such as enterosynes, able to modulate the ENS-induced duodenal contraction is considered a pioneering approach.
Highlighting the potential neurologic side effects of Beta-Blockers
In addition to their classical mode of action in the brain, circulating factors may modulate the release of reactive oxygen/nitrogen species (ROS/RNS) from endothelial cells that compose the blood-brain-barrier without entering the brain. Due to their high capacity to diffuse across membranes, ROS/RNS can reach neurons and modify their activity. This study investigates other mechanisms of actions in which beta-blockers may display a central effect without crossing the blood brain barrier.
Treating metabolic disorders by targeting the enteric nervous system: “Enterosynes” as therapeutic gut factors
The gut-brain axis is of crucial importance for controlling glucose homeostasis. Alteration of this axis promotes the type 2 diabetes phenotype. Recently, a new concept has emerged to demonstrate the crucial role of the enteric nervous system in the control of glycaemia via the hypothalamus.
Cell&Soft & Enterosys combine their expertise
Enterosys provides in vitro models closer to physiology for dermo cosmetic applications.
Enterosys analyzes the efficacy of dermocosmetic assets.
The preclinical services platform SkinObs dedicated to dermocosmetics describes Enterosys’ innovative approach to evaluate the antioxidant capacity of active ingredients
White paper ENTEROSYS
« GUT IS THE LINK »
Our first white paper is now available !
Get inside the head of our co-founder Claude Knauf.
Come discover his background, his key dates, how he got the gut feeling and the link between enteric neurons and glycemic control as well as other health related areas.
Do you have a question about the contribution of gut models in your innovative research ?
Our team of experts will be delighted to answer all of your questions. We guide you in the design of an optimized protocol to meet your objectives and add value to your molecules with quick and concrete solutions.